Quantitative Bioscience at the University of Tennessee

Computational Systems Biology

Computational systems biology aims to develop and use efficient algorithms, data structures, visualization and communication tools with the goal of computer modelling of biological systems. It involves the use of computer simulations of biological systems, including cellular subsystems, such as the networks of metabolites and enzymes which comprise metabolism, signal transduction pathways and gene regulatory networks, to both analyze and visualize the complex connections of these cellular processes. Computational systems biology aims to understand whole systems, from cells to organs to individuals to ecosystems, both in terms of their component parts and their emergent behaviors. Such diverse systems can all be studied and understood using cutting-edge modeling, analytical and numerical techniques, computer simulations, statistics, informatics, and data analysis of biological systems.

	Department	Research Interests
Steve Abel Email	Chemical and Biomolecular Engineering	Computational cell biology and immunology, theory and simulation of soft biological materials, membrane and polymer biophysics, systems biology
Scott Emrich Email	Electrical Engineering & Computer Science	Genome-focused bioinformatics, high-throughput and parallel computing, life science applications
Tian Hong Email	Biochemistry and Cellular & Molecular Biology	Computational systems biology
Rachel Patton McCord Email	Biochemistry & Cellular and Molecular Biology	3D genome structure and the biophysics of cell migration
Dan Roberts Email	Biochemistry & Cellular and Molecular Biology	Biochemistry and biophysics of plant membrane transporters/channels, calcium regulatory proteins
Elena Shpak Email	Biochemistry & Cellular and Molecular Biology	Plant growth and development, signal transduction in Arabidopsis
Mike Simpson Email	Materials Science and Engineering; Center for Nanophase Materials Sciences, ORNL	Nanobioscience, nanobiotechnology
Jeremy Smith Email	Governor's Chair for Molecular Biophysics; Biochemistry & Cellular and Molecular Biology	Computational molecular biophysics, supercomputing, neutrons, drug design. Director, Center for Molecular Biophysics, ORNL
Xiaopeng Zhao Email	Mechanical, Aerospace, and Biomedical Engineering	Biommedical signal processing, medical informatics, dynamics and control, computational biology

NIMBioS
1122 Volunteer Blvd., Suite 106
University of Tennessee
Knoxville, TN 37996-3410
PH: (865) 974-9334
FAX: (865) 974-9461
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From 2008 until early 2021, NIMBioS was supported by the National Science Foundation through NSF Award #DBI-1300426, with additional support from The University of Tennessee, Knoxville. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.