Project for Research Experiences for Undergraduates

NIMBioS Summer Program, June 10 - August 2, 2013

Title: Modeling protein translation and genome evolution

Mentors:
Dr. Mike Gilchrist
Dr. Tuoc Phan

Protein translation, an important step in gene expression that assembles the proteins used throughout the cell, is one of the most fundamental and conserved biological processes. Yet like all biological processes translation has intrinsic costs and processing errors. Due to redundancy inherent in the genetic code (e.g. codons GAA and GAG both code for glutamic acid), the evolution of coding sequences will be influenced by these costs and errors. The goal of this summer's research be to use mathematical models of the intra-ribosomal processes responsible for the costs and errors during protein translation in order to study the patterns found within the genomes of different organisms. The outcome of this work will be a better understanding of how the ribosome works and, in turn, our ability to extract information from genomic sequences.

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Abstract of project report (PDF)

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From 2008 until early 2021, NIMBioS was supported by the National Science Foundation through NSF Award #DBI-1300426, with additional support from The University of Tennessee, Knoxville. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.