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Presentations for NIMBioS Investigative Workshop:

Mathematical Models of Metabolism and Body Weight Regulation, July 12-15, 2011

Tuesday July 12

Introduction to NIMBioS (Lou Gross)
Introduction of participants
Mathematical body weight regulation models from bench to bedside: Navigating translational research (Diana M. Thomas)

Modeling Human Weight Change

History of Human Weight Change Models (Steven B. Heymsfield)
Setpoint, body composition, metabolic adaptation, and weight loss dynamics (Frank Kozusko)
Open problems in obesity modelling (Carson Chow)

Modeling Energy Expenditure

Modeling Human Energy Expenditure (Kevin D. Hall)
Energy expenditure in response to changes in energy intake and physical activity (Klaas Westerterp)
Energy Expenditure following weight loss. Is it abnormally low? (Gary Hunter)
Open group discussion

Wednesday July 13

Measuring and Monitoring Adherence

Measuring adherence by clinical methods (Sai Das)
TBA (Corby Martin)

Modeling weight change in pregnancy and children

Mathematical modelling of weight gain and weight loss in children (Nancy Butte)
A model for gestational weight gain (Diana Thomas)

Poster Session

Energy density of body tissue (Dale Schoeller)
Adipose tissue growth and development (Vipul Periwal)
An Approach To Modeling Tracer Experiments In Metabolic Non-Steady States (Robert Phair)

Discussion groups

Breakout Session 1: Parameter Estimation (Chair: Dale Schoeller)
Description: In this breakout session, discussion will focus on how different parameters are measured and how experiments may be designed to improve their estimation. Some of the parameters of focus are, baseline total energy expenditures, energy density of fat free mass, baseline body composition, baseline resting metabolic rate, percent metabolic adaptation, cost of energy deposition, and the parameter relating the change in spontaneous physical activity to total energy expenditures during weight change.
Breakout Session 2: Variance and modelling (Chair: Kevin Hall)
Description: Variance in day to day measured weight, total energy expenditures, body composition, resting metabolic rates can affect modelling and predictions. In this breakout session, variance in weight over long periods of time will be shown and how this variance impacts modelling and clinical application of model predictions will be discussed.
Breakout Session 3: Objective Measures of Physical Activity (Chair: Nancy Butte)
Description: There has been an explosion of portable devices to monitor free-living day to day physical activity. Data collected from the devices are applied to objectively determine physical activity. In this breakout session, examples of the devices and the resulting data will be shown and discussion of how to mine and apply the data for use within models will follow.
Discussion group reports to full workshop

Thursday July 14

Population/Epidemiological Modeling

Adding expandability limits of the various fat compartments and its metabolic consequences to models predicting body weight gain. (Thorkild Sørensen)
TBA (Gary Sacks)
Physical activity energy expenditure has not declined since the 1980s and matches energy expenditure of wild mammals (Klaas Westerterp)

Open discussion

Modeling weight change and disease

Game theoretic approach to cancer metabolism (Irina Kareva)
Modeling cancer-associated weight loss. (Kevin Hall)
Discussion groups
Summary of Breakout Sessions-Discuss Future Directions with all participants

Friday July 15

Open discussion
Wrap up and future directions (Diana Thomas)
Free time for collaboration

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From 2008 until early 2021, NIMBioS was supported by the National Science Foundation through NSF Award #DBI-1300426, with additional support from The University of Tennessee, Knoxville. Any opinions, findings, and conclusions or recommendations expressed in this material are those of the author(s) and do not necessarily reflect the views of the National Science Foundation.
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